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1

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

Joris Deelen, Hae-Won Uh, Ramin Monajemi, Diana van Heemst, Peter E. Thijssen, Stefan Böhringer, Erik B. van den Akker, Anton J. M. de Craen, Fernando Rivadeneira, André G. Uitterlinden, Rudi G. J. We

Journal:

Year:

2013

Language:

english

File:

PDF, 483 KB

english, 2013

2

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots

Jacobs, Leonie C, Hamer, Merel A, Gunn, David A, Deelen, Joris, Lall, Jaspal S, van Heemst, Diana, Uh, Hae-Won, Hofman, Albert, Uitterlinden, André G, Griffiths, Christopher E M, Beekman, Marian, Slag

Journal:

The Journal of Investigative Dermatology

Year:

2015

Language:

english

File:

PDF, 1.39 MB

english, 2015

3

Natriuretic peptides in the central nervous system: Novel targets for cognitive impairment

Mahinrad, Simin, de Craenn, Anton J.M., Yasar, Sevil, van Heemst, Diana, Sabayan, Behnam

Journal:

Neuroscience & Biobehavioral Reviews

Year:

2016

Language:

english

File:

PDF, 696 KB

english, 2016

4

Classification for Longevity Potential: The Use of Novel Biomarkers

Beekman, Marian, Uh, Hae-Won, van Heemst, Diana, Wuhrer, Manfred, Ruhaak, L. Renee, Gonzalez-Covarrubias, Vanessa, Hankemeier, Thomas, Houwing-Duistermaat, Jeanine J., Slagboom, P. Eline

Journal:

Frontiers in Public Health

Year:

2016

Language:

english

File:

PDF, 448 KB

english, 2016

5

Activity recognition using wearable sensors for tracking the elderly

Paraschiakos, Stylianos, Cachucho, Ricardo, Moed, Matthijs, van Heemst, Diana, Mooijaart, Simon, Slagboom, Eline P., Knobbe, Arno, Beekman, Marian

Journal:

User Modeling and User-Adapted Interaction

Year:

2020

File:

PDF, 2.36 MB

2020

6

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

Nicole S. Verkaik, Rebecca E. E. Esveldt-van Lange, Diana van Heemst, Hennie T. Brüggenwirth, Jan H. J. Hoeijmakers, Malgorzata Z. Zdzienicka, Dik C. van Gent

Journal:

European Journal of Immunology

Year:

2002

Language:

english

File:

PDF, 130 KB

english, 2002

7

Rapid flow cytometric method for measuring senescence associated β-galactosidase activity in human fibroblasts

Gerard Noppe, Pim Dekker, Corine de Koning-Treurniet, Joke Blom, Diana van Heemst, Roeland W. Dirks, Hans J. Tanke, Rudi G. J. Westendorp, Andrea B. Maier

Journal:

Cytometry Part A

Year:

2009

Language:

english

File:

PDF, 270 KB

english, 2009

8

Sister chromatid cohesion and recombination in meiosis

Diana van Heemst, Christa Heyting

Journal:

Year:

2000

Language:

english

File:

PDF, 271 KB

english, 2000

9

Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study

Maris Kuningas, Simon P. Mooijaart, P. Eline Slagboom, Rudi G. J. Westendorp, Diana van Heemst

Journal:

Year:

2006

Language:

english

File:

PDF, 192 KB

english, 2006

10

Lipid metabolism in long-lived families: the Leiden Longevity Study

Anika A. M. Vaarhorst, Marian Beekman, Eka H. D. Suchiman, Diana van Heemst, Jeanine J. Houwing-Duistermaat, Rudi G. J. Westendorp, P. Eline Slagboom, Bastiaan T. Heijmans, On behalf of the project gr

Journal:

Year:

2011

Language:

english

File:

PDF, 176 KB

english, 2011

11

Serum triiodothyronine levels and inflammatory cytokine production capacity

Maarten P. Rozing, Rudi G. J. Westendorp, Andrea B. Maier, Carolien A. Wijsman, Marijke Frölich, Anton J. M. de Craen, Diana van Heemst

Journal:

Year:

2012

Language:

english

File:

PDF, 181 KB

english, 2012

12

C-reactive protein and glucose regulation in familial longevity

Maarten P. Rozing, Simon P. Mooijaart, Marian Beekman, Carolien A. Wijsman, Andrea B. Maier, Andrzej Bartke, Rudi G.J. Westendorp, Eline P. Slagboom, Diana van Heemst

Journal:

Year:

2011

Language:

english

File:

PDF, 180 KB

english, 2011

13

Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study

Carmen M. Martin-Ruiz, Jacobijn Gussekloo, Diana van Heemst, Thomas von Zglinicki, Rudi G. J. Westendorp

Journal:

Year:

2005

Language:

english

File:

PDF, 91 KB

english, 2005

14

Persistence of high-replicative capacity in cultured fibroblasts from nonagenarians

Andrea B. Maier, Saskia Le Cessie, Corine De Koning-Treurniet, Johanna Blom, Rudi G. J. Westendorp, Diana Van Heemst

Journal:

Year:

2007

Language:

english

File:

PDF, 161 KB

english, 2007

15

Genes encoding longevity: from model organisms to humans

Maris Kuningas, Simon P. Mooijaart, Diana Van Heemst, Bas J. Zwaan, P. Eline Slagboom, Rudi G. J. Westendorp

Journal:

Year:

2008

Language:

english

File:

PDF, 137 KB

english, 2008

16

Stress-induced responses of human skin fibroblasts in vitro reflect human longevity

Pim Dekker, Andrea B. Maier, Diana Van Heemst, Corine De Koning-Treurniet, Joke Blom, Roeland W. Dirks, Hans J. Tanke, Rudi G.J. Westendorp

Journal:

Year:

2009

Language:

english

File:

PDF, 228 KB

english, 2009

17

Familial longevity is marked by enhanced insulin sensitivity

Carolien A. Wijsman, Maarten P. Rozing, Trea C. M. Streefland, Saskia le Cessie, Simon P. Mooijaart, P. Eline Slagboom, Rudi G. J. Westendorp, Hanno Pijl, Diana van Heemst, On behalf of the Leiden Lon

Journal:

Year:

2011

Language:

english

File:

PDF, 269 KB

english, 2011

18

Reduced insulin/IGF-1 signalling and human longevity

Diana Van Heemst, Marian Beekman, Simon P. Mooijaart, Bastiaan T. Heijmans, Bernd W. Brandt, Bas J. Zwaan, P. Eline Slagboom, Rudi G. J. Westendorp

Journal:

Year:

2005

Language:

english

File:

PDF, 87 KB

english, 2005

19

Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study

Rudi G.J. Westendorp, Diana Van Heemst, Maarten P. Rozing, Marijke Frölich, Simon P. Mooijaart, Gerard-Jan Blauw, Marian Beekman, Bastiaan T. Heijmans, Anton J.M. De Craen, P. Eline Slagboom, for the

Journal:

Journal of the American Geriatrics Society

Year:

2009

Language:

english

File:

PDF, 77 KB

english, 2009

20

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age

Kuningas, Maris, Mägi, Reedik, Westendorp, Rudi G J, Slagboom, P Eline, Remm, Maido, van Heemst, Diana

Journal:

European Journal of Human Genetics

Year:

2007

Language:

english

File:

PDF, 148 KB

english, 2007

21

Plasma Levels of Apolipoprotein E and Risk of Stroke in Old Age

PETER VAN VLIET, SIMON P. MOOIJAART, ANTON J. M. DE CRAEN, PATRICK C. N. RENSEN, DIANA VAN HEEMST, RUDI G. J. WESTENDORP

Journal:

Annals of the New York Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 78 KB

english, 2007

22

Plasma Levels of Apolipoprotein E and Cognitive Function in Old Age

SIMON P. MOOIJAART, PETER VAN VLIET, DIANA VAN HEEMST, PATRICK C. N. RENSEN, JIMMY F. P. BERBÉE, JELLE JOLLES, ANTON J. M. DE CRAEN, RUDI G. J. WESTENDORP

Journal:

Annals of the New York Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 139 KB

english, 2007

23

β-Galactosidase Activity as a Biomarker of Replicative Senescence during the Course of Human Fibroblast Cultures

ANDREA B. MAIER, RUDI G. J. WESTENDORP, DIANA VAN HEEMST

Journal:

Annals of the New York Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 84 KB

english, 2007

24

The maintenance gap: a new theoretical perspective on the evolution of aging

Maarten J. Wensink, Diana van Heemst, Maarten P. Rozing, Rudi G. J. Westendorp

Journal:

Year:

2012

Language:

english

File:

PDF, 148 KB

english, 2012

25

Variation in the SHC1 gene and longevity in humans

Simon P Mooijaart, Diana van Heemst, Jeroen Schreuder, Suzan van Gerwen, Marian Beekman, Bernd W Brandt, P Eline Slagboom, Rudi G.J Westendorp, on behalf of the ‘Long Life’ study group

Journal:

Experimental Gerontology

Year:

2004

Language:

english

File:

PDF, 132 KB

english, 2004

26

Variation in the human TP53 gene affects old age survival and cancer mortality

Diana van Heemst, Simon P. Mooijaart, Marian Beekman, Jeroen Schreuder, Anton J.M. de Craen, Bernd W. Brandt, P. Eline Slagboom, Rudi G.J. Westendorp, on behalf of the ‘Long Life’ study group

Journal:

Experimental Gerontology

Year:

2005

Language:

english

File:

PDF, 131 KB

english, 2005

27

Impact of genetic variations in the WRN gene on age related pathologies and mortality

Maris Kuningas, P. Eline Slagboom, Rudi G.J. Westendorp, Diana van Heemst

Journal:

Mechanisms of Ageing and Development

Year:

2006

Language:

english

File:

PDF, 286 KB

english, 2006

28

Influence of the TP53 codon 72 polymorphism on the cellular responses to X-irradiation in fibroblasts from nonagenarians

P. Martijn den Reijer, Andrea B. Maier, Rudi G.J. Westendorp, Diana van Heemst

Journal:

Mechanisms of Ageing and Development

Year:

2008

Language:

english

File:

PDF, 465 KB

english, 2008

29

The number of p16INK4a positive cells in human skin reflects biological age

Mariëtte E.C. Waaijer, William E. Parish, Barbara H. Strongitharm, Diana van Heemst, Pieternella E. Slagboom, Anton J.M. de Craen, John M. Sedivy, Rudi G.J. Westendorp, David A. Gunn, Andrea B. Maier

Journal:

Year:

2012

Language:

english

File:

PDF, 369 KB

english, 2012

30

Isolation and Characterization of Sexual Sporulation Mutants of Aspergillus nidulans

Klaas Swart, Diana van Heemst, Marijke Slakhorst, Fons Debets, Christa Heyting

Journal:

Fungal Genetics and Biology

Year:

2001

Language:

english

File:

PDF, 242 KB

english, 2001

31

End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4

Diana van Heemst, Linda Brugmans, Nicole S. Verkaik, Dik C. van Gent

Journal:

Year:

2004

Language:

english

File:

PDF, 199 KB

english, 2004

32

VDR gene variants associate with cognitive function and depressive symptoms in old age

Maris Kuningas, Simon P. Mooijaart, Jelle Jolles, P. Eline Slagboom, Rudi G.J. Westendorp, Diana van Heemst

Journal:

Neurobiology of Aging

Year:

2009

Language:

english

File:

PDF, 188 KB

english, 2009

33

Spo76p Is a Conserved Chromosome Morphogenesis Protein that Links the Mitotic and Meiotic Programs

Diana van Heemst, Françoise James, Stefanie Pöggeler, Véronique Berteaux-Lecellier, Denise Zickler

Journal:

Year:

1999

Language:

english

File:

PDF, 453 KB

english, 1999

34

Biology of cancer and ageing

Diana van Heemst

Journal:

European Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 54 KB

english, 2009

35

Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts

Dekker, Pim, Gunn, David, McBryan, Tony, Dirks, Roeland W., van Heemst, Diana, Lim, Fei-Ling, Jochemsen, Aart G., Verlaan-de Vries, Matty, Nagel, Julia, Adams, Peter D., Tanke, Hans J., Westendorp, Ru

Journal:

Mechanisms of Ageing and Development

Year:

2012

Language:

english

File:

PDF, 687 KB

english, 2012

36

Gene expression analysis of mTOR pathway: association with human longevity

Passtoors, Willemijn M., Beekman, Marian, Deelen, Joris, van der Breggen, Ruud, Maier, Andrea B., Guigas, Bruno, Derhovanessian, Evelyna, van Heemst, Diana, de Craen, Anton J. M., Gunn, David A., Pawe

Journal:

Year:

2013

Language:

english

File:

PDF, 147 KB

english, 2013

37

Cortisol serum levels in familial longevity and perceived age: The Leiden Longevity Study

Noordam, Raymond, Gunn, David A., Tomlin, Cyrena C., Rozing, Maarten P., Maier, Andrea B., Slagboom, P. Eline, Westendorp, Rudi G.J., van Heemst, Diana, de Craen, Anton J.M.

Journal:

Psychoneuroendocrinology

Year:

2012

Language:

english

File:

PDF, 293 KB

english, 2012

38

Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study

Mariette E. C. Waaijer, David A. Gunn, Sharon D. Catt, Michael van Ginkel, Anton J. M. de Craen, Nicole M. Hudson, Diana van Heemst, P. Eline Slagboom, Rudi G. J. Westendorp, Andrea B. Maier

Journal:

Year:

2012

Language:

english

File:

PDF, 313 KB

english, 2012

39

High serum glucose levels are associated with a higher perceived age

Raymond Noordam, David A. Gunn, Cyrena C. Tomlin, Andrea B. Maier, Simon P. Mooijaart, P. Eline Slagboom, Rudi G. J. Westendorp, Anton J. M. de Craen, Diana van Heemst

Journal:

Year:

2013

Language:

english

File:

PDF, 138 KB

english, 2013

40

MicroRNA-663 induction upon oxidative stress in cultured human fibroblasts depends on the chronological age of the donor

Waaijer, Mariëtte E. C., Wieser, Matthias, Grillari-Voglauer, Regina, Heemst, Diana, Grillari, Johannes, Maier, Andrea B.

Journal:

Year:

2014

Language:

english

File:

PDF, 254 KB

english, 2014

41

Renal function in familial longevity: the Leiden Longevity Study

de Goeij, Moniek C.M., Halbesma, Nynke, Dekker, Friedo W., Wijsman, Carolien A., van Heemst, Diana, Maier, Andrea B., Mooijaart, Simon P., Slagboom, P. Eline, Westendorp, Rudi G.J., de Craen, Anton J.

Journal:

Experimental Gerontology

Year:

2014

Language:

english

File:

PDF, 355 KB

english, 2014

42

Acute stress-induced cortisol elevations mediate reward system activity during subconscious processing of sexual stimuli

Oei, Nicole Y.L., Both, Stephanie, van Heemst, Diana, van der Grond, Jeroen

Journal:

Psychoneuroendocrinology

Year:

2014

Language:

english

File:

PDF, 520 KB

english, 2014

43

Human in vivo longevity is reflected in vitro by differential metabolism as measured by 1H-NMR profiling of cell culture supernatants

Dekker, Pim, Meissner, Axel, Dirks, Roeland W., Eline Slagboom, P., van Heemst, Diana, Deelder, André M., Tanke, Hans J., Westendorp, Rudi G. J., Maier, Andrea B.

Journal:

Molecular BioSystems

Year:

2012

Language:

english

File:

PDF, 1.44 MB

english, 2012

44

Disentangling the effects of circulating IGF-1, glucose, and cortisol on features of perceived age

van Drielen, Kelly, Gunn, David A., Noordam, Raymond, Griffiths, Christopher E. M., Westendorp, Rudi G. J., de Craen, Anton J. M., van Heemst, Diana

Journal:

Year:

2015

Language:

english

File:

PDF, 859 KB

english, 2015

45

Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength

Beenakker, Karel G. M., Westendorp, Rudi G. J., de Craen, Anton J. M., Slagboom, Pieternella E., van Heemst, Diana, Maier, Andrea B.

Journal:

Year:

2013

Language:

english

File:

PDF, 240 KB

english, 2013

46

Ambulant 24-h glucose rhythms mark calendar and biological age in apparently healthy individuals

Wijsman, Carolien A., van Heemst, Diana, Hoogeveen, Evelien S., Slagboom, P. Eline, Maier, Andrea B., de Craen, Anton J. M., van der Ouderaa, Frans, Pijl, Hanno, Westendorp, Rudi G. J., Mooijaart, Sim

Journal:

Year:

2013

Language:

english

File:

PDF, 263 KB

english, 2013

47

Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age

Akintola, Abimbola A., van den Berg, Annette, van Buchem, Mark A., Jansen, Steffy W., Slagboom, Eline P., Westendorp, Rudi G., van der Grond, Jeroen, van Heemst, Diana

Journal:

Frontiers in Aging Neuroscience

Year:

2015

Language:

english

File:

PDF, 958 KB

english, 2015

48

Insulin, Aging, and the Brain: Mechanisms and Implications

Akintola, Abimbola A., van Heemst, Diana

Journal:

Frontiers in Endocrinology

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

49

Mental Performance in Old Age Dependent on Cortisol and Genetic Variance in the Mineralocorticoid and Glucocorticoid Receptors

Kuningas, Maris, de Rijk, Roel H, Westendorp, Rudi G J, Jolles, Jelle, Eline Slagboom, P, van Heemst, Diana

Journal:

Neuropsychopharmacology

Year:

2007

Language:

english

File:

PDF, 120 KB

english, 2007

50

Physiological Responding to Stress in Middle-Aged Males Enriched for Longevity: A Social Stress Study

Jansen, Steffy W. M., van Heemst, Diana, van der Grond, Jeroen, Westendorp, Rudi, Oei, Nicole Y. L.

Journal:

Year:

2015

Language:

english

File:

PDF, 839 KB

english, 2015

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